![]() “We think this is a possible driver of persistent symptoms,” Strle said. In patients with high levels of interferon-alpha, the immune response to the Lyme bacteria may cause chronic inflammation, even once the infection is gone, said Klemen Strle, an assistant research professor of molecular biology and microbiology at Tufts University and an author of the new study. If the blood levels are too high, the immune system can overact, causing pain, swelling and fatigue - symptoms often seen with Lyme disease. You may also experience a worsening of earlier Lyme disease symptoms.Interferon-alpha is one of a handful of key signaling proteins the body makes to tell immune cells to fight off bacteria or viruses. If you are experiencing any of these heart symptoms, seek immediate medical care. Inflammation of the heart (carditis) that can cause heart palpitations, irregular heartbeat, dizziness, shortness of breath, or fainting. Weakness or drooping on one or both sides of the face difficulty closing an eyelid (facial palsy) Numbness, weakness, or tingling in the arms and legs (radiculoneuritis) Inflammation of the brain and spinal cord (meningitis), which can cause severe headache, neck stiffness, and sensitivity to light and sound Pain that may come and go and move around the body, in joints, tendons, muscles, and bones More than one EM rash (a sign very suggestive of Lyme disease) Lyme disease that has moved to the brain is sometimes referred to as Lyme neuroborreliosis, or neurological Lyme disease.Ĭommon symptoms of early disseminated Lyme disease include: In early disseminated Lyme disease, the infection has started to move beyond the site of your tick bite to other parts of your body such as your heart, brain, or spinal cord. Timing: Weeks to months after a tick bite You may notice swollen lymph nodes anywhere on your body, not just near the area of your tick bite. Lymph nodes, which contain immune cells that help fight infection, are located throughout your body, including your neck and armpits. Typically, no redness or swelling accompanies the pain. That means you might feel it in different places on different days. Muscle or joint pain that moves around (is migratory). However, up to 30% of people with Lyme disease never develop or notice an EM rash.įatigue, malaise, and lethargy (you might feel like you have the flu) EM rash only occurs in people with Lyme disease. (See sidebar, "Not all Lyme disease rashes look like bullseyes.") Migrans means spreading, and an important characteristic of an EM rash is that it expands over time. However, it can also be a solid red, expanding rash of a different shape. ![]() The rash often has a bullseye or target-like shape. Rash, known as an erythema migrans (EM) rash. Timing: Within days or up to one month after a tick bite Or someone might develop Stage 3 symptoms months or years after a tick bite, without ever having had or noticed symptoms of early infection. ![]() For example, a person might get diagnosed and treated in Stage 1, and never experience Stages 2 or 3. Lyme disease stages can also overlap, and not everyone experiences all stages, or all symptoms of each stage. While Lyme disease stages and associated symptoms tend to develop on the timeline described below, symptoms can appear earlier. This is more likely if you are not diagnosed and treated early. Over time the Lyme disease bacteria can spread, or disseminate, to other parts of the body, causing more serious symptoms associated with early disseminated (Stage 2) or late disseminated (Stage 3) Lyme disease. Common symptoms of early localized Lyme disease include a rash or mild, flulike symptoms. ![]() Early localized, or Stage 1, Lyme disease occurs soon after being infected, when the Lyme disease bacteria are still close to the site of the tick bite. (For more information, see Diagnosis and Testing). If you develop symptoms listed below, especially after you’ve gotten a tick bite or spent time in an area where Lyme disease is common, you can ask your doctor whether you might have Lyme disease and if you should be tested for it. If you don’t have a Lyme disease diagnosis, it’s helpful to know that Lyme disease can cause a variety of seemingly unrelated symptoms throughout your body. Lyme disease symptoms are more likely to progress if you have not been appropriately treated. You’ll also be able to watch for signs that could mean that your Lyme disease has progressed. If you have already been diagnosed with Lyme disease, learning about Lyme disease stages can help you know what symptoms you might experience.
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